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2093386-22-0

2093386-22-0 structure
2093386-22-0 structure
  • Name: PROTAC BET Degrader-1
  • Chemical Name: PROTAC 11
  • CAS Number: 2093386-22-0
  • Molecular Formula: C44H45N11O9
  • Molecular Weight: 871.9
  • Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
  • Create Date: 2018-09-07 22:09:05
  • Modify Date: 2024-01-16 18:02:23
  • PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.
Name PROTAC 11
Description PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.
Related Catalog
Target

BET[1]

In Vitro PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC50 of 4.3 nM, and 45.5 nM for MOLM-13 cells[1].
References

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
Molecular Formula C44H45N11O9
Molecular Weight 871.9

Chemsrc provides CAS#:2093386-22-0 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2093386-22-0 | Chemsrc address: https://www.chemsrc.com/en/baike/1555424.html

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