2241019-57-6

2241019-57-6 structure

Name: NAMPT inhibitor-linker 1
Chemical Name: NAMPT inhibitor-linker 1
CAS Number: 2241019-57-6
Molecular Formula: C₃₆H₃₇FN₆O₆
Molecular Weight: 668.71
Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
Create Date: 2019-03-03 10:07:07
Modify Date: 2024-01-11 10:55:01
NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.

Name	NAMPT inhibitor-linker 1

Description	NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt
In Vitro	ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pM and 9 pM, respectively[1].
In Vivo	ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1]. Animal Model: Female scid-beige (SCID bg) mice[1] Dosage: 20 mg/kg Administration: A single intravenous injection (i.v.) for 28 days Result: Significantly inhibited the growth of tumor in mice.
References	[1]. Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

Molecular Formula	C₃₆H₃₇FN₆O₆
Molecular Weight	668.71