2241014-82-2
2241014-82-2 structure
- Name: NAMPT inhibitor-linker 2
- Chemical Name: NAMPT inhibitor-linker 2
- CAS Number: 2241014-82-2
- Molecular Formula: C34H33FN6O5
- Molecular Weight: 624.66
- Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
- Create Date: 2019-03-03 19:53:05
- Modify Date: 2024-01-09 23:42:10
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NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
| Name | NAMPT inhibitor-linker 2 |
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| Description | NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively. |
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| Related Catalog | |
| In Vitro | ADC-4 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively[1]. ADC-4 (0.01 nM-10 nM, 144 hours) inhibits cell proliferation of GIST-T1 cells, but does not affect the cell cycle[1]. Cell Proliferation Assay[1] Cell Line: GIST-T1 cells Concentration: 0.1 pM-10 nM Incubation Time: 144 hours Result: Inhibited the cell proliferation of GIST-T1 cells at 0.01-10 nM, and the inhibition remained unchanged after 1 nM. |
| In Vivo | ADC-4 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1]. Animal Model: Female scid-beige (SCID bg) mice[1] Dosage: 20 mg/kg Administration: A single intravenous injection (i.v.) for 28 days Result: Significantly inhibited the growth of tumor in mice. |
| References |
| Molecular Formula | C34H33FN6O5 |
|---|---|
| Molecular Weight | 624.66 |