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1638526-94-9

1638526-94-9 structure
1638526-94-9 structure
  • Name: Bax activator compound 106
  • Chemical Name: Bax activator-1
  • CAS Number: 1638526-94-9
  • Molecular Formula: C29H36N4O3
  • Molecular Weight: 488.62
  • Catalog: Signaling Pathways Apoptosis Bcl-2 Family
  • Create Date: 2019-06-02 13:53:33
  • Modify Date: 2024-01-11 18:56:38
  • Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1].

Name Bax activator-1
Description Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1].
Related Catalog
Target

Bax

In Vitro Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion[1]. Apoptosis Analysis[1] Cell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells Concentration: 20 μM, 40 μM , 60 μM , 80 μM Incubation Time: 48 hours Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.
In Vivo Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1]. Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1] Dosage: 40 mg/kg Administration: Given i.p., each day for 13 days Result: Exhibited anti-tumor activity as a single-agent.
References

[1]. Zhao G, et al. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol. 2014 Apr;34(7):1198-207.

Molecular Formula C29H36N4O3
Molecular Weight 488.62