244021-67-8

244021-67-8 structure

Name: Indirubin-5-sulfonate
Chemical Name: Indirubin-5-sulfonate
CAS Number: 244021-67-8
Molecular Formula: C₁₆H₁₀N₂O₅S
Molecular Weight: 342.33
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2019-06-01 19:50:56
Modify Date: 2024-01-10 18:34:58
Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].

Name	Indirubin-5-sulfonate

Description	Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	Cdk1/cyclin B:55 nM (IC50) cdk2/cyclin A:35 nM (IC50) CDK2/cyclinE:150 nM (IC50) Cdk4/cyclin D1:300 nM (IC50) CDK5/p35:65 nM (IC50) GSK-3β
References	[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

Molecular Formula	C₁₆H₁₀N₂O₅S
Molecular Weight	342.33