358721-70-7
358721-70-7 structure
- Name: UBCS039
- Chemical Name: UBCS039
- CAS Number: 358721-70-7
- Molecular Formula: C16H13N3
- Molecular Weight: 247.29
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2019-06-02 07:40:11
- Modify Date: 2024-01-05 23:36:03
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UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1].
| Name | UBCS039 |
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| Description | UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1]. |
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| Related Catalog | |
| Target |
SIRT6:38 μM (EC50) |
| In Vitro | UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells[2]. UBCS039 leads to autophagosome accumulation in human cancer cells[2]. UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation[2]. Western Blot Analysis[2] Cell Line: Human H1299 cells. Concentration: 75 μM. Incubation Time: 48 and 72 hours. Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. Western Blot Analysis[2] Cell Line: Human H1299 cells. Concentration: 75 μM. Incubation Time: 48 and 72 hours. Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. Cell Proliferation Assay[2] Cell Line: Human H1299 cells. Concentration: 100 μM. Incubation Time: 48 and 72 hours. Result: Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines. |
| References |
| Molecular Formula | C16H13N3 |
|---|---|
| Molecular Weight | 247.29 |
| Storage condition | 2-8℃ |