2095849-04-8
2095849-04-8 structure
- Name: CSF1R-IN-1
- Chemical Name: CSF1R-IN-1
- CAS Number: 2095849-04-8
- Molecular Formula: C25H20F3N5O2
- Molecular Weight: 479.45
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
- Create Date: 2019-06-04 18:07:41
- Modify Date: 2024-01-10 09:15:16
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CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.
| Name | CSF1R-IN-1 |
|---|
| Description | CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.5 nM (CSF1R)[1] |
| In Vitro | CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay[1]. |
| In Vivo | CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept.[1]. Animal Model: Male CD-1 mice, 25-35 grams (8-11 weeks old)[1] Dosage: 2 mg/kg IV or 10 mg/kg orally (Per Os) Administration: i.v. or oral Result: I.V.: Cmax=3.55, T1/2=0.87P.O.: Cmax=4.6, T1/2=1.8, Bioavailability=64% |
| References |
| Molecular Formula | C25H20F3N5O2 |
|---|---|
| Molecular Weight | 479.45 |