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926906-64-1

926906-64-1 structure
926906-64-1 structure
  • Name: VRX-0466617
  • Chemical Name: VRX-0466617
  • CAS Number: 926906-64-1
  • Molecular Formula: C19H20BrN5O2S
  • Molecular Weight: 462.36
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Checkpoint Kinase (Chk)
  • Create Date: 2019-08-07 19:49:23
  • Modify Date: 2024-01-08 20:20:58
  • VRX0466617, a selective Chk2 inhibitor, inhibits the phosphorylation of Chk2 Ser 19 and Ser33-35. VRX0466617 can be used in the study of cancer[1].

Name VRX-0466617
Synonyms 5-({4-[(4-bromophenyl)amino]phenyl}amino)-3-hydroxy-N-(1-hydroxypropan-2-yl)-1,2-thiazole-4-carboximidamide
4-Isothiazolecarboximidamide, 5-[[4-[(4-bromophenyl)amino]phenyl]amino]-2,3-dihydro-N-(2-hydroxy-1-methylethyl)-3-oxo-
5-({4-[(4-Bromophenyl)amino]phenyl}amino)-N-(1-hydroxy-2-propanyl)-3-oxo-2,3-dihydro-1,2-thiazole-4-carboximidamide
Description VRX0466617, a selective Chk2 inhibitor, inhibits the phosphorylation of Chk2 Ser 19 and Ser33-35. VRX0466617 can be used in the study of cancer[1].
Related Catalog
References

[1]. Carlessi L, et al. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther. 2007 Mar;6(3):935-44.  

Density 1.6±0.1 g/cm3
Boiling Point 545.4±60.0 °C at 760 mmHg
Molecular Formula C19H20BrN5O2S
Molecular Weight 462.36
Flash Point 283.6±32.9 °C
Exact Mass 461.052094
LogP 3.06
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.714
Storage condition store at -20℃ for one year(Powder)