1848959-10-3
1848959-10-3 structure
- Name: TAS4464
- Chemical Name: TAS4464
- CAS Number: 1848959-10-3
- Molecular Formula: C21H23FN6O6S
- Molecular Weight: 506.51
- Catalog: Signaling Pathways Metabolic Enzyme/Protease NEDD8-activating Enzyme
- Create Date: 2019-06-29 09:17:05
- Modify Date: 2024-01-24 21:36:47
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TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1].
| Name | TAS4464 |
|---|---|
| Synonyms | MFCD32067967 |
| Description | TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50：0.955 nM (NAE)[1] |
| In Vitro | TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines. |
| References |
| Molecular Formula | C21H23FN6O6S |
|---|---|
| Molecular Weight | 506.51 |