2108806-02-4

2108806-02-4 structure
2108806-02-4 structure
  • Name: JNJ-37822681 dihydrochloride
  • Chemical Name: JNJ-37822681 dihydrochloride
  • CAS Number: 2108806-02-4
  • Molecular Formula: C17H19Cl2F5N4
  • Molecular Weight: 445.26
  • Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
  • Create Date: 2019-08-03 20:18:58
  • Modify Date: 2024-01-12 18:39:26
  • JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1].

Name JNJ-37822681 dihydrochloride
Description JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1].
Related Catalog
Target

Ki: 158 nM (dopamine D(2))[1]

References

[1]. Langlois X, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.

Molecular Formula C17H19Cl2F5N4
Molecular Weight 445.26