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544707-19-9

544707-19-9 structure
544707-19-9 structure
  • Name: JNJ 10181457 dihydrochloride
  • Chemical Name: 4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine
  • CAS Number: 544707-19-9
  • Molecular Formula: C20H28N2O
  • Molecular Weight: 312.45
  • Create Date: 2016-12-15 09:03:24
  • Modify Date: 2024-01-13 00:43:43
  • JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1].

Name 4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine
Description JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1].
Related Catalog
In Vivo JNJ 10181457 (1 mg/kg,i.v.) 在雄性 Wistar 大鼠中,相比于生理盐水对照组,可以阻断组胺 (50 μg/kg) 或甲硫美哌 (50 μg/kg) 产生的迷走神经诱发的心动过缓反应的抑制作用[1]。
References

[1]. Mónica García, et al. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):113-21.  

Molecular Formula C20H28N2O
Molecular Weight 312.45
Exact Mass 384.17400
PSA 15.71000
LogP 4.22610