544707-19-9

544707-19-9 structure

Name: JNJ 10181457 dihydrochloride
Chemical Name: 4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine
CAS Number: 544707-19-9
Molecular Formula: C₂₀H₂₈N₂O
Molecular Weight: 312.45
Create Date: 2016-12-15 09:03:24
Modify Date: 2024-01-13 00:43:43
JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1].

Name	4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine

Description	JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vivo	JNJ 10181457 (1 mg/kg，i.v.) 在雄性 Wistar 大鼠中，相比于生理盐水对照组，可以阻断组胺 (50 μg/kg) 或甲硫美哌 (50 μg/kg) 产生的迷走神经诱发的心动过缓反应的抑制作用[1]。
References	[1]. Mónica García, et al. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):113-21.