JNJ 10181457 dihydrochloride
Modify Date: 2024-01-13 00:43:43
JNJ 10181457 dihydrochloride structure
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Common Name | JNJ 10181457 dihydrochloride | ||
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| CAS Number | 544707-19-9 | Molecular Weight | 312.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H28N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ 10181457 dihydrochlorideJNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1]. |
| Name | 4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine |
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| Description | JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1]. |
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| Related Catalog | |
| In Vivo | JNJ 10181457 (1 mg/kg，i.v.) 在雄性 Wistar 大鼠中，相比于生理盐水对照组，可以阻断组胺 (50 μg/kg) 或甲硫美哌 (50 μg/kg) 产生的迷走神经诱发的心动过缓反应的抑制作用[1]。 |
| References |
| Molecular Formula | C20H28N2O |
|---|---|
| Molecular Weight | 312.45 |
| Exact Mass | 384.17400 |
| PSA | 15.71000 |
| LogP | 4.22610 |