1949801-52-8

1949801-52-8 structure

Name: LXRβ agonist-2
Chemical Name: LXRβ agonist-2
CAS Number: 1949801-52-8
Molecular Formula: C₃₂H₃₁F₆N₃O₇
Molecular Weight: 683.59
Catalog: Signaling Pathways Metabolic Enzyme/Protease LXR
Create Date: 2019-08-04 10:55:58
Modify Date: 2024-01-04 23:18:20
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].

Name	LXRβ agonist-2

Description	LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> LXR
Target	EC50: 7 nM (LXRβ), 200 nM (LXRα)[1]
References	[1]. Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46.

Molecular Formula	C₃₂H₃₁F₆N₃O₇
Molecular Weight	683.59