309935-58-8

309935-58-8 structure
309935-58-8 structure
  • Name: Tubulysin E
  • Chemical Name: Tubulysin E
  • CAS Number: 309935-58-8
  • Molecular Formula: C42H63N5O9S
  • Molecular Weight: 814.04
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2019-09-09 18:01:50
  • Modify Date: 2024-01-02 17:37:09
  • Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Name Tubulysin E
Description Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].
Related Catalog
References

[1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.

[2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

Molecular Formula C42H63N5O9S
Molecular Weight 814.04
Hazard Codes Xi