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2113650-05-6

2113650-05-6 structure
2113650-05-6 structure
  • Name: BMS-1166 hydrochloride
  • Chemical Name: BMS-1166 hydrochloride
  • CAS Number: 2113650-05-6
  • Molecular Formula: C36H34Cl2N2O7
  • Molecular Weight: 677.57
  • Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
  • Create Date: 2019-10-07 20:13:52
  • Modify Date: 2024-01-03 20:09:26
  • BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

Name BMS-1166 hydrochloride
Description BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
Related Catalog
Target

IC50: 1.4 nM (PD-1/PD-L1 interaction)[1].

In Vitro BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].
References

[1]. Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867.

[2]. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.

Molecular Formula C36H34Cl2N2O7
Molecular Weight 677.57