1471172-27-6

1471172-27-6 structure

Name: DPM-1001
Chemical Name: DPM-1001
CAS Number: 1471172-27-6
Molecular Formula: C₃₅H₅₇N₃O₃
Molecular Weight: 567.85
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2019-10-07 20:04:46
Modify Date: 2024-01-07 08:53:52
DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property[1].

Name	DPM-1001

Description	DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
Target	IC50: 100 nM (PTP1B)[1]
References	[1]. Krishnan N, et al. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525.

Molecular Formula	C₃₅H₅₇N₃O₃
Molecular Weight	567.85