2064175-32-0

2064175-32-0 structure

Name: dTAG-7
Chemical Name: FKBP12 PROTAC dTAG-7
CAS Number: 2064175-32-0
Molecular Formula: C₆₃H₇₉N₅O₁₉
Molecular Weight: 1210.32
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-10-07 09:44:04
Modify Date: 2024-01-11 10:03:37
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].

Name	FKBP12 PROTAC dTAG-7

Description	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	FKBP12(F36V) BRD4 Cereblon
References	[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.

Molecular Formula	C₆₃H₇₉N₅O₁₉
Molecular Weight	1210.32