900308-84-1

900308-84-1 structure

Name: SEC inhibitor KL-1
Chemical Name: SEC inhibitor KL-1
CAS Number: 900308-84-1
Molecular Formula: C₁₈H₁₆ClNO₄
Molecular Weight: 345.78
Catalog: Research Areas Cancer
Create Date: 2019-10-08 16:20:52
Modify Date: 2024-01-10 00:10:14
SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].

Name	SEC inhibitor KL-1

Description	SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	SEC[1]
References	[1]. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.

Molecular Formula	C₁₈H₁₆ClNO₄
Molecular Weight	345.78