900308-51-2

900308-51-2 structure

Name: SEC inhibitor KL-2
Chemical Name: SEC inhibitor KL-2
CAS Number: 900308-51-2
Molecular Formula: C₁₇H₁₃ClFNO₃
Molecular Weight: 333.74
Catalog: Research Areas Cancer
Create Date: 2019-10-04 17:37:12
Modify Date: 2024-01-06 11:30:25
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].

Name	SEC inhibitor KL-2

Description	SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	SEC[1]
References	[1]. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.

Molecular Formula	C₁₇H₁₃ClFNO₃
Molecular Weight	333.74