1035638-91-5
1035638-91-5 structure
- Name: PF 6274484
- Chemical Name: PF-6274484
- CAS Number: 1035638-91-5
- Molecular Formula: C18H14ClFN4O2
- Molecular Weight: 372.781
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2020-01-12 20:33:50
- Modify Date: 2024-04-03 07:24:36
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PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively).
| Name | PF-6274484 |
|---|---|
| Synonyms |
PF-6274484
MFCD30182370 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]- N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}acrylamide |
| Description | PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). |
|---|---|
| In Vitro | PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively).It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively). |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 578.3±50.0 °C at 760 mmHg |
| Molecular Formula | C18H14ClFN4O2 |
| Molecular Weight | 372.781 |
| Flash Point | 303.5±30.1 °C |
| Exact Mass | 372.078918 |
| LogP | 3.87 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.691 |
| Storage condition | -20°C |