1239600-18-0
1239600-18-0 structure
- Name: LMT-28
- Chemical Name: LMT-28
- CAS Number: 1239600-18-0
- Molecular Formula: C17H29NO4
- Molecular Weight: 311.417
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2020-01-11 19:57:59
- Modify Date: 2024-01-08 08:55:55
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LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130; does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells; binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex; inhibits IL-6–induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5 uM; inhibits IL-6–induced TNF-α production, ameliorates the progression of pancreatitis in mice.
| Name | LMT-28 |
|---|---|
| Synonyms |
(4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone
2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)- LMT-28 (4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylenenonanoyl]-4-isopropyl-1,3-oxazolidin-2-one |
| Description | LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130; does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells; binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex; inhibits IL-6–induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5 uM; inhibits IL-6–induced TNF-α production, ameliorates the progression of pancreatitis in mice. |
|---|---|
| References | References 1. Hong SS, et al. J Immunol. 2015 Jul 1;195(1):237-45. 2. Armstead WM, et al. Transl Stroke Res. 2018 Feb 23. doi: 10.1007/s12975-018-0617-z. View Related Products by Target Interleukin Receptor |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 452.9±38.0 °C at 760 mmHg |
| Molecular Formula | C17H29NO4 |
| Molecular Weight | 311.417 |
| Flash Point | 227.7±26.8 °C |
| Exact Mass | 311.209656 |
| LogP | 3.05 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.493 |
| Storage condition | -20°C |