792184-90-8

792184-90-8 structure

Name: ASP 2905
Chemical Name: N2-(4-Fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine
CAS Number: 792184-90-8
Molecular Formula: C₂₀H₁₇FN₈
Molecular Weight: 388.401
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2020-01-12 05:22:42
Modify Date: 2024-01-22 00:37:18
ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats. Alzheimer Disease Phase 1 Discontinued

Name	N2-(4-Fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine
Synonyms	1,3,5-Triazine-2,4,6-triamine, N2-(4-fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)- N2-(4-Fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine

Description	ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats. Alzheimer Disease Phase 1 Discontinued
References	References 1. Takahashi S, et al. Eur J Pharmacol. 2017 Sep 5;810:26-35. View Related Products by Target Potassium Channel Alzheimer Disease