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  • DC Chemicals Limited
  • China
  • Product Name: BI-99179
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1291779-76-4

1291779-76-4 structure
1291779-76-4 structure
  • Name: BI99179
  • Chemical Name: (1R,3S)-N-[4-(1,3-Benzoxazol-2-yl)phenyl]-N-methyl-3-(propionylamino)cyclopentanecarboxamide
  • CAS Number: 1291779-76-4
  • Molecular Formula: C23H25N3O3
  • Molecular Weight: 391.463
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Fatty Acid Synthase (FAS)
  • Create Date: 2020-01-12 00:35:59
  • Modify Date: 2024-04-05 15:59:07
  • BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM; demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM; BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target.

Name (1R,3S)-N-[4-(1,3-Benzoxazol-2-yl)phenyl]-N-methyl-3-(propionylamino)cyclopentanecarboxamide
Synonyms Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)-
(1R,3S)-N-[4-(1,3-Benzoxazol-2-yl)phenyl]-N-methyl-3-(propionylamino)cyclopentanecarboxamide
Description BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM; demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM; BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target.
Related Catalog
Target

IC50: 79 nM (FAS)[1]

In Vitro BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1].
In Vivo BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg)with half life (t1/2) of 3.0 h[1].
References

[1]. Kley JT, et al. Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.

Density 1.3±0.1 g/cm3
Boiling Point 603.1±55.0 °C at 760 mmHg
Molecular Formula C23H25N3O3
Molecular Weight 391.463
Flash Point 318.5±31.5 °C
Exact Mass 391.189606
LogP 3.12
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.633