2894848-07-6

2894848-07-6 structure

Name: BI‑3231
Chemical Name: BI‑3231
CAS Number: 2894848-07-6
Molecular Formula: C₁₆H₁₄F₂N₄O₃S
Molecular Weight: 380.37
Catalog: Research Areas Metabolic Disease
Create Date: 2023-05-24 11:54:36
Modify Date: 2024-01-30 20:15:39
BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases[1].

Name	BI‑3231

Description	BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13)[1]
In Vitro	BI 3231 在肝微粒体中表现出高代谢稳定性，在肝细胞中表现出中等代谢稳定性[1]。
In Vivo	BI 3231 从血浆中迅速清除，但在 48 h 内仍保持相当大的肝脏暴露[1]。
References	[1]. Thamm S, et, al. Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem. 2023 Feb 2.

Molecular Formula	C₁₆H₁₄F₂N₄O₃S
Molecular Weight	380.37