BI99179
Modify Date: 2024-04-05 15:59:07
BI99179 structure
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Common Name | BI99179 | ||
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| CAS Number | 1291779-76-4 | Molecular Weight | 391.463 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 603.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H25N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 318.5±31.5 °C | |
Use of BI99179BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM; demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM; BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target. |
| Name | (1R,3S)-N-[4-(1,3-Benzoxazol-2-yl)phenyl]-N-methyl-3-(propionylamino)cyclopentanecarboxamide |
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| Synonym | More Synonyms |
| Description | BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM; demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM; BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target. |
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| Related Catalog | |
| Target |
IC50: 79 nM (FAS)[1] |
| In Vitro | BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1]. |
| In Vivo | BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg)with half life (t1/2) of 3.0 h[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 603.1±55.0 °C at 760 mmHg |
| Molecular Formula | C23H25N3O3 |
| Molecular Weight | 391.463 |
| Flash Point | 318.5±31.5 °C |
| Exact Mass | 391.189606 |
| LogP | 3.12 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.633 |
| Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)- |
| (1R,3S)-N-[4-(1,3-Benzoxazol-2-yl)phenyl]-N-methyl-3-(propionylamino)cyclopentanecarboxamide |