158093-65-3
158093-65-3 structure
- Name: PU-139
- Chemical Name: 2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one
- CAS Number: 158093-65-3
- Molecular Formula: C12H7FN2OS
- Molecular Weight: 246.260
- Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
- Create Date: 2020-01-12 07:48:52
- Modify Date: 2024-01-13 13:28:17
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PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300; triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo.
| Name | 2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one |
|---|---|
| Synonyms |
2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one
Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-fluorophenyl)- |
| Description | PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300; triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo. |
|---|---|
| References | References 1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137. 2. Carneiro VC, et al. PLoS Pathog. 2014 May 8;10(5):e1004116. 3. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. View Related Products by Target Histone Acetyltransferase (HAT) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 434.3±51.0 °C at 760 mmHg |
| Molecular Formula | C12H7FN2OS |
| Molecular Weight | 246.260 |
| Flash Point | 216.5±30.4 °C |
| Exact Mass | 246.026306 |
| LogP | 1.83 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.686 |