158093-65-3

158093-65-3 structure

Name: PU-139
Chemical Name: 2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one
CAS Number: 158093-65-3
Molecular Formula: C₁₂H₇FN₂OS
Molecular Weight: 246.260
Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
Create Date: 2020-01-12 07:48:52
Modify Date: 2024-01-13 13:28:17
PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300; triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo.

Name	2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one
Synonyms	2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-fluorophenyl)-

Description	PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300; triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo.
References	References 1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137. 2. Carneiro VC, et al. PLoS Pathog. 2014 May 8;10(5):e1004116. 3. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. View Related Products by Target Histone Acetyltransferase (HAT)