DC Chemicals Limited
China
Product Name: PU-02
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-[(1-Naphthalenylmethyl)thio]-9H-purine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

313984-77-9

313984-77-9 structure

Name: PU 02
Chemical Name: 6-[(1-Naphthylmethyl)sulfanyl]-7H-purine
CAS Number: 313984-77-9
Molecular Formula: C₁₆H₁₂N₄S
Molecular Weight: 292.35800
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-10-20 13:27:34
Modify Date: 2024-01-09 18:10:08
PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].

Name	6-[(1-Naphthylmethyl)sulfanyl]-7H-purine
Synonyms	MFCD23381174

Description	PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT3A Receptor:0.36 μM (IC50) 5-HT 3 AB:0.73 μM (IC50)
In Vitro	PU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC50=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment[2]. PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells[2]. PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected[2]. PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity[2]. Apoptosis Analysis[2] Cell Line: HepG2 cells. Concentration: 6.26, 12.5, 25, 50 μM. Incubation Time: 6, 12, 24, 36 h. Result: Induced mitochondria-dependent apoptosis.
References	[1]. Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20;287(30):25241-54. [2]. Xiao-Guang Yang, et al. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15;695(1-3):27-33.

Molecular Formula	C₁₆H₁₂N₄S
Molecular Weight	292.35800
Exact Mass	292.07800
PSA	79.76000
LogP	3.79840

Hazard Codes	Xi

313984-77-9	817635-93-1
1202865-65-3	158093-65-3
1454619-13-6	1454619-14-7
873436-91-0	168334-34-7
324579-65-9	246857-02-3