313984-77-9
313984-77-9 structure
- Name: PU 02
- Chemical Name: 6-[(1-Naphthylmethyl)sulfanyl]-7H-purine
- CAS Number: 313984-77-9
- Molecular Formula: C16H12N4S
- Molecular Weight: 292.35800
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-10-20 13:27:34
- Modify Date: 2024-01-09 18:10:08
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PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].
| Name | 6-[(1-Naphthylmethyl)sulfanyl]-7H-purine |
|---|---|
| Synonyms | MFCD23381174 |
| Description | PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2]. |
|---|---|
| Related Catalog | |
| Target |
5-HT3A Receptor:0.36 μM (IC50) 5-HT 3 AB:0.73 μM (IC50) |
| In Vitro | PU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC50=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment[2]. PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells[2]. PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected[2]. PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity[2]. Apoptosis Analysis[2] Cell Line: HepG2 cells. Concentration: 6.26, 12.5, 25, 50 μM. Incubation Time: 6, 12, 24, 36 h. Result: Induced mitochondria-dependent apoptosis. |
| References |
| Molecular Formula | C16H12N4S |
|---|---|
| Molecular Weight | 292.35800 |
| Exact Mass | 292.07800 |
| PSA | 79.76000 |
| LogP | 3.79840 |
| Hazard Codes | Xi |
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