862811-76-5
862811-76-5 structure
- Name: DRV1 (GPR32) agonist C2A
- Chemical Name: 3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide
- CAS Number: 862811-76-5
- Molecular Formula: C20H14F2N4O
- Molecular Weight: 364.348
- Create Date: 2020-01-11 13:04:49
- Modify Date: 2024-01-15 00:48:04
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DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli.
| Name | 3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide |
|---|---|
| Synonyms |
Benzamide, 3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]-
3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide |
| Description | DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli. |
|---|---|
| References | References 1. Chiang N, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H14F2N4O |
| Molecular Weight | 364.348 |
| Exact Mass | 364.113556 |
| LogP | 3.72 |
| Index of Refraction | 1.654 |