Name | N-Butyl-11-(3-chloro-4-fluorophenyl)dibenzo[b,f][1,4]thiazepine-8 -carboxamide |
---|
Description | CB1 inverse agonist 2 is an orally active inverse agonist of Cannabinoid Receptor CB1. CB1 inverse agonist 2 effectively inhibits CP55940-induced hypothermia and anorexia in mice model[1]. |
---|---|
Related Catalog | |
Target |
CB1:9.7 (pKi) CB2:6.0 (pKi) |
In Vitro | CB1 inverse agonist 2 (compound 12 h) 对 CB1 具有选择性,对 CB1 和 CB2 的 pKi 值分别为 9.7 和 6.0[1]。 |
In Vivo | CB1 inverse agonist 2 (compound 12 h) (1 mg/kg; 腹腔注射; 单次剂量) 对体温降低的抑制程度达到 70%,(10mg /kg;口服; 单剂量) 对食物摄入的抑制率达到 59%[1]。 CB1 inverse agonist 2 (10 mg/kg; 口服; 每天一次,持续 14 天) 导致小鼠体重与初始体重相比,出现 13% 的减轻[1]。 |
References |
Molecular Formula | C24H20ClFN2OS |
---|---|
Molecular Weight | 438.94500 |
Exact Mass | 438.09700 |
PSA | 70.25000 |
LogP | 6.65310 |