852315-00-5
852315-00-5 structure
- Name: CB1 inverse agonist 1
- Chemical Name: CB1 inverse agonist 1
- CAS Number: 852315-00-5
- Molecular Formula: C25H18Cl3N3O3
- Molecular Weight: 514.79
- Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
- Create Date: 2020-04-18 18:14:31
- Modify Date: 2024-01-06 14:54:05
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CB1 inverse agonist 1 is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects[1].
| Name | CB1 inverse agonist 1 |
|---|
| Description | CB1 inverse agonist 1 is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects[1]. |
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| Related Catalog | |
| Target |
CB1:7.5 nM (IC50) CB2:4100 nM (IC50) |
| In Vivo | CB1 inverse agonist 1 (Compound 14; 0.3, 1, or 3 mg/kg）inhibits feeding in a dose-dependent manner[1]. The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively[1]. Animal Model: Rat[1] Dosage: 0.3, 1, or 3 mg/kg Administration: PO Result: Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels. |
| References |
| Molecular Formula | C25H18Cl3N3O3 |
|---|---|
| Molecular Weight | 514.79 |