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2135514-20-2

2135514-20-2 structure
2135514-20-2 structure
  • Name: APJ receptor agonist 5
  • Chemical Name: APJ receptor agonist 5
  • CAS Number: 2135514-20-2
  • Molecular Formula: C26H29N3O6
  • Molecular Weight: 479.52
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2022-05-06 11:19:06
  • Modify Date: 2024-01-12 21:44:11
  • APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].

Name APJ receptor agonist 5
Description APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].
Related Catalog
References

[1]. Meng W, et al. Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure. J Med Chem. 2021;64(24):18102-18113.

Molecular Formula C26H29N3O6
Molecular Weight 479.52