1965244-85-2

1965244-85-2 structure

Name: APJ receptor agonist 6
Chemical Name: APJ receptor agonist 6
CAS Number: 1965244-85-2
Molecular Formula: C₂₉H₃₄FN₃O₅
Molecular Weight: 523.60
Catalog: Research Areas Cardiovascular Disease
Create Date: 2022-09-18 17:53:15
Modify Date: 2024-08-14 17:50:16
APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].

Name	APJ receptor agonist 6

Description	APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	EC50: 0.800 ± 0.1 μM (Apelin Receptor calcium), 0.844 ± 0.2 μM (Apelin Receptor cAMP), 6.22 ± 2.0 μM (Apelin Receptor β-arrestin), >10 μM (AT1 calcium)[1]
References	[1]. Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237.

Molecular Formula	C₂₉H₃₄FN₃O₅
Molecular Weight	523.60