2166378-92-1

2166378-92-1 structure

Name: Glucocorticoid receptor agonist-2
Chemical Name: Glucocorticoid receptor agonist-2
CAS Number: 2166378-92-1
Molecular Formula: C₃₄H₃₅F₂NO₇
Molecular Weight: 607.64
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2023-01-18 23:20:36
Modify Date: 2024-04-09 19:09:38
Glucocorticoid receptor agonist-2 (compound 21) is an Glucocorticoid Receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373[1].

Name	Glucocorticoid receptor agonist-2

Description	Glucocorticoid receptor agonist-2 (compound 21) is an Glucocorticoid Receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Glucocorticoid receptor agonist-2 对糖皮质激素受体 (GR) 和孕激素受体 (PR) 结合的 IC50 值分别为 6.6 和 7.3 nM[1]。 Glucocorticoid receptor agonist-2 对糖皮质激素效应元件 (GRE) 报告基因和盐皮质激素受体 (MR) 的 EC50 值分别为 0.2 和 442 nM[1]。 Glucocorticoid receptor agonist-2 对盐皮质激素受体激动活性的 EC50 值为 149 nM[1]。
References	[1]. Mcpherson MJ, et al. Preparation of glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471. 2017.

Molecular Formula	C₃₄H₃₅F₂NO₇
Molecular Weight	607.64