2108830-09-5
2108830-09-5 structure
- Name: TH1834 dihydrochloride
- Chemical Name: TH1834 dihydrochloride
- CAS Number: 2108830-09-5
- Molecular Formula: C33H42Cl2N6O3
- Molecular Weight: 641.638
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-12 09:34:50
- Modify Date: 2024-01-12 17:44:37
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TH1834 dihydrochloride (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor; induces apoptosis in breast cancer cell lines with more cytotoxicity than staurosporine; increases the γH2AX foci in the cancer cell lines PC-3 and DU-145 combined with IR; induces apoptosis and increases unrepaired DNA damage in breast cancer cells.
| Name | TH1834 dihydrochloride |
|---|
| Description | TH1834 dihydrochloride (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor; induces apoptosis in breast cancer cell lines with more cytotoxicity than staurosporine; increases the γH2AX foci in the cancer cell lines PC-3 and DU-145 combined with IR; induces apoptosis and increases unrepaired DNA damage in breast cancer cells. |
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| Related Catalog | |
| In Vitro | TH1834 (0-500 μM; 1 hour; MCF7 cells) treatment significantly reduces the viability of MCF7 cells[1]. TH1834 (0-500 μM; 1 hour; MCF7 cells) treatment highly significant increase in cytotoxicity[1]. TH1834 (500 μM; 1 hour; MCF7 cells) treatment induces caspase 3 activation in MCF7 cells[1]. TH1834 significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage in breast cancer[1]. Cell Viability Assay[1] Cell Line: MCF7 cells Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time: 1 hour Result: Significantly reduced the viability of MCF7 cells. Cell Cytotoxicity Assay[1] Cell Line: MCF7 cells Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time: 1 hour Result: Highly significant increase in cytotoxicity at all concentrations used. Western Blot Analysis[1] Cell Line: MCF7 cells Concentration: 500 μM Incubation Time: 1 hour Result: Marked caspase 3 activation was observed in MCF7 cells in an independent assay. |
| References |
| Molecular Formula | C33H42Cl2N6O3 |
|---|---|
| Molecular Weight | 641.638 |