1027642-43-8

1027642-43-8 structure

Name: BAY 60-2770
Chemical Name: BAY 60-2770
CAS Number: 1027642-43-8
Molecular Formula: C₃₅H₃₃F₄NO₅
Molecular Weight: 623.645
Catalog: Signaling Pathways GPCR/G Protein Guanylate Cyclase
Create Date: 2020-01-11 16:42:15
Modify Date: 2024-01-16 17:42:49
BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM; demonstrates vasodilator activity in the pulmonary and systemic vascular beds that is enhanced by ODQ and NOS inhibition.

Name	BAY 60-2770

Description	BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM; demonstrates vasodilator activity in the pulmonary and systemic vascular beds that is enhanced by ODQ and NOS inhibition.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase
In Vivo	BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models[1]. BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice[2]. Animal Model: Obese mice[2] Dosage: 1 mg/kg Administration: p.o.; daily from the 10th to the 12th week Result: Ameliorates detrusor dysfunction in obese mice.
References	[1]. Knorr A, et al. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung. 2008;58(2):71-80. [2]. Leiria LO, et al. The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice. J Urol. 2014 Feb;191(2):539-47.

Molecular Formula	C₃₅H₃₃F₄NO₅
Molecular Weight	623.645