1427304-84-4

1427304-84-4 structure

Name: NBD-11021
Chemical Name: NBD-11021
CAS Number: 1427304-84-4
Molecular Formula: C₂₂H₂₅ClN₄O₂S
Molecular Weight: 444.978
Create Date: 2020-01-20 13:32:57
Modify Date: 2024-04-06 08:23:00
A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM). HIV Preclinical

Name	NBD-11021

Description	A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM). HIV Preclinical
References	References 1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927. View Related Products by Target HIV HIV

Molecular Formula	C₂₂H₂₅ClN₄O₂S
Molecular Weight	444.978