2234273-72-2
2234273-72-2 structure
- Name: NBD-14189
- Chemical Name: NBD-14189
- CAS Number: 2234273-72-2
- Molecular Formula: C18H16F4N4O2S
- Molecular Weight: 428.40
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2022-04-07 19:30:00
- Modify Date: 2024-01-14 17:30:08
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NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. NBD-14189 binds to HIV-1 gp120 and shows potent antiviral activity (EC50<200 nM)[1][2].
| Name | NBD-14189 |
|---|
| Description | NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. NBD-14189 binds to HIV-1 gp120 and shows potent antiviral activity (EC50<200 nM)[1][2]. |
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| Related Catalog | |
| Target |
HIV-1 |
| In Vitro | NBD-14189 has anti-HIV-1 activity (IC50=0.089 μM) and cytotoxicity (CC50=21.9 μM) in single-cycle (TZM-bl cells) assays. NBD-14189 has anti-HIV-1 activity (IC50=0.18 μM) and cytotoxicity (CC50=22.1 μM) in multi-cycle (MT-2 cells) assays[1]. NBD-14189 (0-50 μM) prevents HIV-1 mediated cell-cell fusion with an IC50 of 9.4 μM in indicator cells TZM-bl cells were cocultured with Env- and Tat-expressing HL2/3 cells[1]. NBD-14189 shows weak or no inhibition of the hERG current, with an IC50 of 3.0 μM, respectively[1]. |
| References |
| Molecular Formula | C18H16F4N4O2S |
|---|---|
| Molecular Weight | 428.40 |