1478364-87-2
1478364-87-2 structure
- Name: PXS-4681A
- Chemical Name: PXS-4681A
- CAS Number: 1478364-87-2
- Molecular Formula: C10H14ClFN2O3S
- Molecular Weight: 296.741
- Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
- Create Date: 2020-01-11 19:38:49
- Modify Date: 2024-01-13 20:52:50
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A potent, selective, and irreversible inhibitor of SSAO/VAP-1 (AOC3) with Ki of 37 nM, IC50 of <10 nM; displays 250- and 4000-fold selectivity over DAO and LOX; attenuates neutrophil migration, TNF-α, and IL-6 levels in mouse models of lung inflammation and localized inflammation;orally activie.
| Name | PXS-4681A |
|---|
| Description | A potent, selective, and irreversible inhibitor of SSAO/VAP-1 (AOC3) with Ki of 37 nM, IC50 of <10 nM; displays 250- and 4000-fold selectivity over DAO and LOX; attenuates neutrophil migration, TNF-α, and IL-6 levels in mouse models of lung inflammation and localized inflammation;orally activie. |
|---|---|
| References | References 1. Foot JS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74. 2. Becchi S, et al. Br J Pharmacol. 2017 Jul;174(14):2302-2317. View Related Products by Target Other Targets |
| Molecular Formula | C10H14ClFN2O3S |
|---|---|
| Molecular Weight | 296.741 |