155514-72-0
155514-72-0 structure
- Name: IRES-J007
- Chemical Name: IRES-J007
- CAS Number: 155514-72-0
- Molecular Formula: C17H15NO4
- Molecular Weight: 297.31
- Create Date: 2020-01-20 19:14:55
- Modify Date: 2024-10-01 12:48:50
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An improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.
| Name | IRES-J007 |
|---|
| Description | An improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242. |
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| References | References 1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc |
| Molecular Formula | C17H15NO4 |
|---|---|
| Molecular Weight | 297.31 |