IRES-J007
Modify Date: 2024-10-01 12:48:50
IRES-J007 structure
|
Common Name | IRES-J007 | ||
|---|---|---|---|---|
| CAS Number | 155514-72-0 | Molecular Weight | 297.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H15NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IRES-J007An improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242. |
| Name | IRES-J007 |
|---|
| Description | An improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242. |
|---|---|
| References | References 1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc |
| Molecular Formula | C17H15NO4 |
|---|---|
| Molecular Weight | 297.31 |