IRES-C11
Modify Date: 2024-09-16 16:45:40
IRES-C11 structure
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Common Name | IRES-C11 | ||
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| CAS Number | 342416-30-2 | Molecular Weight | 316.137 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 415.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C13H11Cl2NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 205.3±28.7 °C | |
Use of IRES-C11A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells; shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation; significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib; shows synergistic anti-MM cytotoxicity combined with ER stress inducers; also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242. |
| Name | 3,4-Dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione |
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| Synonym | More Synonyms |
| Description | A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells; shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation; significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib; shows synergistic anti-MM cytotoxicity combined with ER stress inducers; also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242. |
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| References | References 1. Shi Y, et al. Oncogene. 2016 Feb 25;35(8):1015-24. 2. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 415.8±45.0 °C at 760 mmHg |
| Molecular Formula | C13H11Cl2NO4 |
| Molecular Weight | 316.137 |
| Flash Point | 205.3±28.7 °C |
| Exact Mass | 315.006500 |
| LogP | 2.16 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.605 |
| 1H-Pyrrole-2,5-dione, 3,4-dichloro-1-[(2,4-dimethoxyphenyl)methyl]- |
| 3,4-Dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione |