342416-30-2

342416-30-2 structure

Name: IRES-C11
Chemical Name: 3,4-Dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione
CAS Number: 342416-30-2
Molecular Formula: C₁₃H₁₁Cl₂NO₄
Molecular Weight: 316.137
Catalog: Signaling Pathways Apoptosis c-Myc
Create Date: 2020-01-11 19:40:42
Modify Date: 2024-09-16 16:45:40
A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells; shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation; significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib; shows synergistic anti-MM cytotoxicity combined with ER stress inducers; also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242.

Name	3,4-Dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione
Synonyms	1H-Pyrrole-2,5-dione, 3,4-dichloro-1-[(2,4-dimethoxyphenyl)methyl]- 3,4-Dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione

Description	A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells; shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation; significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib; shows synergistic anti-MM cytotoxicity combined with ER stress inducers; also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242.
References	References 1. Shi Y, et al. Oncogene. 2016 Feb 25;35(8):1015-24. 2. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc