1800327-36-9
1800327-36-9 structure
- Name: LEI-105
- Chemical Name: LEI-105
- CAS Number: 1800327-36-9
- Molecular Formula: C25H24N2O2
- Molecular Weight: 384.479
- Create Date: 2020-01-11 18:33:51
- Modify Date: 2024-08-09 19:04:11
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LEI-105 is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor with pIC50 pf 7.5/7.4 respectively; shows no activity against other enzymes involved in endocannabinoid metabolism (ABHD6, ABHD12, MAGL, or FAAH), and no affinity for CB1 receptor; concentration-dependently reduces 2-AG levels, but not anandamide levels, in Neuro2A cells; reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model.
| Name | LEI-105 |
|---|
| Description | LEI-105 is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor with pIC50 pf 7.5/7.4 respectively; shows no activity against other enzymes involved in endocannabinoid metabolism (ABHD6, ABHD12, MAGL, or FAAH), and no affinity for CB1 receptor; concentration-dependently reduces 2-AG levels, but not anandamide levels, in Neuro2A cells; reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model. |
|---|---|
| References | References 1. Baggelaar MP, et al. J Am Chem Soc. 2015 Jul 15;137(27):8851-7. View Related Products by Target Diacylglycerol Lipase (DAGL) |
| Molecular Formula | C25H24N2O2 |
|---|---|
| Molecular Weight | 384.479 |