Name | LEI-106 |
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Synonyms |
N-[(2,2-Dimethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]-N-(4-phenoxybenzyl)glycine
Glycine, N-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]- LEI-106 |
Description | LEI-106 is a potent, dual sn-1-Diacylglycerol lipase α (DAGL-α)/ABHD6 inhibitor with an IC50 of 18 nM for DAGL-α and a Ki of 0.8 μM for ABHD6. LEI-106 inhibits the hydrolysis of [14C]-sn-1-oleoyl-2-arachidonoyl-glycerol, the natural substrate of DAGL-α, with a Ki of 0.7 μM[1]. |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 664.1±65.0 °C at 760 mmHg |
Molecular Formula | C26H27NO6S |
Molecular Weight | 481.561 |
Flash Point | 355.4±34.3 °C |
Exact Mass | 481.155914 |
LogP | 7.75 |
Vapour Pressure | 0.0±2.1 mmHg at 25°C |
Index of Refraction | 1.607 |