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  • DC Chemicals Limited
  • China
  • Product Name: LEI-106
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1620582-23-1

1620582-23-1 structure
1620582-23-1 structure
  • Name: LEI-106
  • Chemical Name: LEI-106
  • CAS Number: 1620582-23-1
  • Molecular Formula: C26H27NO6S
  • Molecular Weight: 481.561
  • Create Date: 2021-05-08 16:31:12
  • Modify Date: 2024-01-16 22:34:40
  • LEI-106 is a potent, dual sn-1-Diacylglycerol lipase α (DAGL-α)/ABHD6 inhibitor with an IC50 of 18 nM for DAGL-α and a Ki of 0.8 μM for ABHD6. LEI-106 inhibits the hydrolysis of [14C]-sn-1-oleoyl-2-arachidonoyl-glycerol, the natural substrate of DAGL-α, with a Ki of 0.7 μM[1].

Name LEI-106
Synonyms N-[(2,2-Dimethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]-N-(4-phenoxybenzyl)glycine
Glycine, N-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]-
LEI-106
Description LEI-106 is a potent, dual sn-1-Diacylglycerol lipase α (DAGL-α)/ABHD6 inhibitor with an IC50 of 18 nM for DAGL-α and a Ki of 0.8 μM for ABHD6. LEI-106 inhibits the hydrolysis of [14C]-sn-1-oleoyl-2-arachidonoyl-glycerol, the natural substrate of DAGL-α, with a Ki of 0.7 μM[1].
Related Catalog
References

[1]. Janssen FJ, et al. Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. J Med Chem. 2014;57(15):6610-6622.

Density 1.3±0.1 g/cm3
Boiling Point 664.1±65.0 °C at 760 mmHg
Molecular Formula C26H27NO6S
Molecular Weight 481.561
Flash Point 355.4±34.3 °C
Exact Mass 481.155914
LogP 7.75
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.607