639074-49-0
639074-49-0 structure
- Name: KSP-IA
- Chemical Name: KSP-IA
- CAS Number: 639074-49-0
- Molecular Formula: C21H22F2N2O
- Molecular Weight: 356.417
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Kinesin
- Create Date: 2020-01-12 11:19:50
- Modify Date: 2024-01-09 12:24:51
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A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM; has no ihibitory activity toward other kinesins, includin CENP-E, MKLP-1, KIF-3A, and uKHC (IC50>50 uM); induces the formation of monoastral spindles, causes mitotic arrest in a dose-dependent manner (EC50=30 nM) in A2780 ovarian carcinoma cells; sustained KSP inhibition activates the proapoptotic protein, Bax, and both activation of the spindle checkpoint and subsequent mitotic slippage are required for Bax activation.
| Name | KSP-IA |
|---|
| Description | A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM; has no ihibitory activity toward other kinesins, includin CENP-E, MKLP-1, KIF-3A, and uKHC (IC50>50 uM); induces the formation of monoastral spindles, causes mitotic arrest in a dose-dependent manner (EC50=30 nM) in A2780 ovarian carcinoma cells; sustained KSP inhibition activates the proapoptotic protein, Bax, and both activation of the spindle checkpoint and subsequent mitotic slippage are required for Bax activation. |
|---|---|
| References | References 1. Tao W, et al. Cancer Cell. 2005 Jul;8(1):49-59. View Related Products by Target Kinesin |
| Molecular Formula | C21H22F2N2O |
|---|---|
| Molecular Weight | 356.417 |