824983-94-0
824983-94-0 structure
- Name: FEN1-IN-C20
- Chemical Name: FEN1-IN-C20
- CAS Number: 824983-94-0
- Molecular Formula: C20H15N3O4S
- Molecular Weight: 393.417
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 17:04:49
- Modify Date: 2023-10-16 17:09:24
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FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM; significantly suppresses cell proliferation and induces DNA damage in lung cancer cells, enhances the therapeutic effect of cisplatin; efficiently suppresses cancer progression in combination with cisplatin in mouse models.
| Name | FEN1-IN-C20 |
|---|
| Description | FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM; significantly suppresses cell proliferation and induces DNA damage in lung cancer cells, enhances the therapeutic effect of cisplatin; efficiently suppresses cancer progression in combination with cisplatin in mouse models. |
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| References | References 1. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21. 2. He L, et al. Mol Oncol. 2017 Jun;11(6):640-654. 3. He L, et al. EBioMedicine. 2016 Dec;14:32-43. View Related Products by Target Other Targets |
| Molecular Formula | C20H15N3O4S |
|---|---|
| Molecular Weight | 393.417 |