2109805-87-8
2109805-87-8 structure
- Name: FEN1-IN-3
- Chemical Name: FEN1-IN-3
- CAS Number: 2109805-87-8
- Molecular Formula: C15H12N2O4
- Molecular Weight: 284.27
- Catalog: Signaling Pathways Others Others
- Create Date: 2020-08-11 15:49:02
- Modify Date: 2024-01-03 18:06:50
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FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1].
| Name | FEN1-IN-3 |
|---|
| Description | FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1]. |
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| Related Catalog | |
| In Vitro | FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1]. |
| References |
| Molecular Formula | C15H12N2O4 |
|---|---|
| Molecular Weight | 284.27 |