- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: FEN1-IN-3
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Huang
- DC Chemicals Limited
- China
- Product Name: FEN1-IN-3
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Tony Cao
2109805-87-8
2109805-87-8 structure
- Name: FEN1-IN-3
- Chemical Name: FEN1-IN-3
- CAS Number: 2109805-87-8
- Molecular Formula: C15H12N2O4
- Molecular Weight: 284.27
- Catalog: Signaling Pathways Others Others
- Create Date: 2020-08-11 15:49:02
- Modify Date: 2024-01-03 18:06:50
-
FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1].
| Name | FEN1-IN-3 |
|---|
| Description | FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1]. |
|---|---|
| Related Catalog | |
| In Vitro | FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1]. |
| References |
| Molecular Formula | C15H12N2O4 |
|---|---|
| Molecular Weight | 284.27 |