155412-88-7

155412-88-7 structure

Name: CCK-B Receptor Antagonist 2
Chemical Name: CCK-B Receptor Antagonist 2
CAS Number: 155412-88-7
Molecular Formula: C₂₇H₂₈N₆O₃
Molecular Weight: 484.55
Catalog: Signaling Pathways GPCR/G Protein Cholecystokinin Receptor
Create Date: 2020-01-24 07:00:51
Modify Date: 2024-01-06 17:35:53
CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1].

Name	CCK-B Receptor Antagonist 2

Description	CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Metabolic Disease
Target	IC50: 0.43 nM (Gastrin/CCK-B); 1.82 μM (Gastrin/CCK-A)[1]
In Vivo	CCK-B Receptor Antagonist 2 (0.1 μmol/kg; intravenous injection) has an inhibition effect on pentagastrin-induced gastric acid secretion in anethsetized rats with an ED50 of 8.3 nmol/kg[1].
References	[1]. Semple G, et al. (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.J Med Chem. 1997 Jan 31;40(3):331-41.

Molecular Formula	C₂₇H₂₈N₆O₃
Molecular Weight	484.55