615273-95-5

615273-95-5 structure

Name: EP2 receptor antagonist-2
Chemical Name: WAY-327111
CAS Number: 615273-95-5
Molecular Formula: C₁₅H₁₄F₃N₃O
Molecular Weight: 309.29
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2023-01-04 19:22:22
Modify Date: 2024-01-31 20:11:43
EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA)[1].

Name	WAY-327111
Synonyms	Morpholine, 4-[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]- 4-(4-Phenyl-6-trifluoromethyl-pyrimidin-2-yl)-morpholine 4-[4-Phenyl-6-(trifluoromethyl)-2-pyrimidinyl]morpholine

Description	EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA)[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	EP
In Vitro	EP2 receptor antagonist-2 对 C6G 细胞具有细胞毒性，CC50 为 575 μM[1]。 EP2 receptor antagonist-2 (20 μM；30 min) 降低大鼠原代海马神经元 (DIV14) 中 NMDA (30 μM) 诱导的 LDH 释放[1]。
References	[1]. Jiang J, et al. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707.