847554-50-1
847554-50-1 structure
- Name: RTI-118
- Chemical Name: RTI-118
- CAS Number: 847554-50-1
- Molecular Formula: C26H32N4O3
- Molecular Weight: 448.56
- Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
- Create Date: 2020-01-23 22:13:51
- Modify Date: 2024-01-10 14:41:06
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RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration[1].
| Name | RTI-118 |
|---|
| Description | RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration[1]. |
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| Related Catalog | |
| In Vitro | RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant[2]. |
| In Vivo | RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in cocaine and food self-administration; however these effects are selective for cocaine at lower doses (10 and 20 mg/kg)[1]. Animal Model: Rat[1] Dosage: 5 mg/kg; 10 mg/kg; 20 mg/kg; 30 mg/kg Administration: Intraperitoneal injection; pre-treatment 30 minutes; 5-30 mg/kg Result: The effects on the reinstatement of extinguished cocaine-seeking behavior are restricted to doses of 20 mg/kg or less. |
| References |
[2]. Bonano JS,et al. Effects of the neuropeptide S receptor antagonist RTI-118 |
| Molecular Formula | C26H32N4O3 |
|---|---|
| Molecular Weight | 448.56 |